Originally clearly intended to be abouut the Jews. Gay fits better than black because one of the key points is that you can hide your mutanthood and "pass". But obviously also extended in recent times to be metaphor for any group that perceives itself as shunned - teeangers, geeks, goths etc etc.
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I suspect it largely comes down to nose size.
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And there was me thinking about Nightcrawler :-P
U still up?